JAG1 CLIA Kit for Human(Homo sapiens) | EIAab.comJAG1 CLIA Kit for Human(Homo sapiens)

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JAG1 (Gene name),

Protein jagged-1 (Protein name ), JAG1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

JAG1(JAGL1);

Protein name:

Protein jagged-1(Jagged1;hJ1);

Alternative:

CD:

CD339;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions).

Function:

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1218

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

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800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1218:

DNRDLESAQS | LNRMEYIV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P78504

STRING:

9606.ENSP00000254958

Pfam:

PF01414

UniGene:

Hs.224012

MIM:

118450

SMR:

P78504

KEGG:

hsa:182

Uniprot:

P78504

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ELISA Kit for Human Jagged1

Cat.:

E2164r

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96T

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ELISA Kit for Human Jagged1

Cat.:

E2164h

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96T

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ELISA Kit for Human Jagged1

Cat.:

E2164m

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96T

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CLIA Kit for Human Jagged1

Cat.:

U2164r

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Packing:

96T

CLIA Kit for Human Jagged1

Cat.:

U2164h

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MSDS:

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Packing:

96T

CLIA Kit for Human Jagged1

Cat.:

U2164m

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Packing:

96T

Polyclonal Antibody for Human Jagged1

Cat.:

P2164Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Jagged1

Cat.:

P2164Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Jagged1

Cat.:

P2164Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Jagged1

Protein for Human Jagged1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12."
Oda T. , Elkahloun A.G. , Meltzer P.S. , Chandrasekharappa S.C.
Genomics43:376-379(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1."
Li L. , Krantz I.D. , Deng Y. , Genin A. , Banta A.B. , Collins C.C. , Qi M. , Trask B.J. , Kuo W.L. , Cochran J. , Costa T. , Pierpont M.E.M. , Rand E.B. , Piccoli D.A. , Hood L. , Spinner N.B.
Nat. Genet.16:243-251(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INVOLVEMENT IN ALGS1;VARIANT ALGS1 CYS-184
tissue: Bone marrow.
3.

"The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1."
Li L. , Milner L.A. , Deng Y. , Iwata M. , Banta A.B. , Graf L. , Marcovina S. , Friedman C. , Trask B.J. , Hood L. , Torok-Storb B.
Immunity8:43-55(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
4.

"Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors."
Bash J. , Zong W.-X. , Banga S. , Rivera A. , Ballard D.W. , Ron Y. , Gelinas C.
EMBO J.18:2803-2811(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Cervix carcinoma.
5.

"Human ligands of the Notch receptor."
Gray G.E. , Mann R.S. , Mitsiadis E. , Henrique D. , Carcangiu M.-L. , Banks A. , Leiman J. , Ward D. , Ish-Horowitz D. , Artavanis-Tsakonas S.
Am. J. Pathol.154:785-794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
7.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
9.

"An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro."
Zimrin A.B. , Pepper M.S. , McMahon G.A. , Nguyen F. , Montesano R. , Maciag T.
J. Biol. Chem.271:32499-32502(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-1218 (ISOFORM 1)
tissue: Umbilical vein endothelial cell.
10.

"Mutations in the human Jagged1 gene are responsible for Alagille syndrome."
Oda T. , Elkahloun A.G. , Pike B.L. , Okajima K. , Krantz I.D. , Genin A. , Piccoli D.A. , Meltzer P.S. , Spinner N.B. , Collins F.S. , Chandrasekharappa S.C.
Nat. Genet.16:235-242(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
11.

"JAGGED1 expression in human embryos: correlation with the Alagille syndrome phenotype."
Jones E.A. , Clement-Jones M. , Wilson D.I.
J. Med. Genet.37:658-662(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition."
Cordle J. , Johnson S. , Tay J.Z. , Roversi P. , Wilkin M.B. , de Madrid B.H. , Shimizu H. , Jensen S. , Whiteman P. , Jin B. , Redfield C. , Baron M. , Lea S.M. , Handford P.A.
Nat. Struct. Mol. Biol.15:849-857(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 185-335;FUNCTION;INTERACTION WITH NOTCH1;DOMAIN;MUTAGENESIS OF PHE-207;DISULFIDE BONDS
14.

"Exon 6 of human JAG1 encodes a conserved structural unit."
Pintar A. , Guarnaccia C. , Dhir S. , Pongor S.
BMC Struct. Biol.9:43-43(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 252-295;DOMAIN;DISULFIDE BONDS
15.

"Spectrum and frequency of Jagged1 (JAG1) mutations in Alagille syndrome patients and their families."
Krantz I.D. , Colliton R.P. , Genin A. , Rand E.B. , Li L. , Piccoli D.A. , Spinner N.B.
Am. J. Hum. Genet.62:1361-1369(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 CYS-184 AND HIS-184
16.

"Mutations in JAGGED1 gene are predominantly sporadic in Alagille syndrome."
Crosnier C. , Driancourt C. , Raynaud N. , Dhorne-Pollet S. , Pollet N. , Bernard O. , Hadchouel M. , Meunier-Rotival M.
Gastroenterology116:1141-1148(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 HIS-79; THR-127; ARG-129; LEU-163; GLY-184; SER-187; GLY-229; PHE-284; CYS-288; PHE-438; SER-731 AND ARG-740
17.

"Jagged-1 mutation analysis in Italian Alagille syndrome patients."
Pilia G. , Uda M. , Macis D. , Frau F. , Crisponi L. , Balli F. , Barbera C. , Colombo C. , Frediani T. , Gatti R. , Iorio R. , Marazzi M.G. , Marcellini M. , Musumeci S. , Nebbia G. , Vajro P. , Ruffa G. , Zancan L. , more...
Hum. Mutat.14:394-400(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 THR-152 AND LEU-184
18.

"Jagged1 (JAG1) mutation detection in an Australian Alagille syndrome population."
Heritage M.L. , MacMillan J.C. , Colliton R.P. , Genin A. , Spinner N.B. , Anderson G.J.
Hum. Mutat.16:408-416(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 TYR-229 AND ARG-386
19.

"Familial tetralogy of Fallot caused by mutation in the Jagged1 gene."
Eldadah Z.A. , Hamosh A. , Biery N.J. , Montgomery R.A. , Duke M. , Elkins R. , Dietz H.C.
Hum. Mol. Genet.10:163-169(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TOF ASP-274
20.

"Defective intracellular transport and processing of JAG1 missense mutations in Alagille syndrome."
Morrissette J.J.D. , Colliton R.P. , Spinner N.B.
Hum. Mol. Genet.10:405-413(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALGS1 SER-37
21.

"Fifteen novel mutations in the JAGGED1 gene of patients with Alagille syndrome."
Crosnier C. , Driancourt C. , Raynaud N. , Hadchouel M. , Meunier-Rotival M.
Hum. Mutat.17:72-73(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 PHE-220 AND ARG-753
22.

"Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients."
Colliton R.P. , Bason L. , Lu F.-M. , Piccoli D.A. , Krantz I.D. , Spinner N.B.
Hum. Mutat.17:151-152(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 ASP-33; SER-37; SER-78; ASN-181; TYR-714 AND SER-902
23.

"Familial deafness, congenital heart defects, and posterior embryotoxon caused by cysteine substitution in the first epidermal-growth-factor-like domain of Jagged 1."
Le Caignec C. , Lefevre M. , Schott J.J. , Chaventre A. , Gayet M. , Calais C. , Moisan J.P.
Am. J. Hum. Genet.71:180-186(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DEAFNESS TYR-234
24.

"The significance of human Jagged 1 mutations detected in severe cases of extrahepatic biliary atresia."
Kohsaka T. , Yuan Z.-R. , Guo S.-X. , Tagawa M. , Nakamura A. , Nakano M. , Kawasasaki H. , Inomata Y. , Tanaka K. , Miyauchi J.
Hepatology36:904-912(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BILIARY ATRESIA LEU-45; ASP-53; MET-65; LYS-203; ASP-690; ARG-871; GLN-908; PRO-921 AND GLN-1213
25.

"DHPLC mutation analysis of Jagged1 (JAG1) reveals six novel mutations in Australian Alagille syndrome patients."
Heritage M.L. , MacMillan J.C. , Anderson G.J.
Hum. Mutat.20:481-481(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 SER-39; HIS-184 AND ARG-913
26.

"Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage."
Lu F. , Morrissette J.J.D. , Spinner N.B.
Am. J. Hum. Genet.72:1065-1070(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT ASP-274
27.

"Identification of 36 novel Jagged1 (JAG1) mutations in patients with Alagille syndrome."
Roepke A. , Kujat A. , Graeber M. , Giannakudis J. , Hansmann I.
Hum. Mutat.21:100-100(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 VAL-31; PRO-40; SER-75; SER-123; ARG-163; CYS-224; LEU-269 AND GLN-937
28.

"Twelve novel JAG1 gene mutations in Polish Alagille syndrome patients."
Jurkiewicz D. , Popowska E. , Glaeser C. , Hansmann I. , Krajewska-Walasek M.
Hum. Mutat.25:321-321(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 ASN-120 AND TYR-187
29.

"Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate."
Warthen D.M. , Moore E.C. , Kamath B.M. , Morrissette J.J.D. , Sanchez P. , Piccoli D.A. , Krantz I.D. , Spinner N.B.
Hum. Mutat.27:436-443(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALGS1 22-CYS--ARG-25 DEL; SER-33; VAL-33; ARG-92; TYR-92; PRO-155; GLY-252; SER-256; ARG-271; SER-504; TYR-693; GLN-889; TYR-911 AND 1055-VAL-ARG-1056 GLY DELINS;VARIANT LYS-818
30.

"Alagille Syndrome: A new missense mutation detected by whole-exome sequencing in a case previously found to be negative by DHPLC and MLPA."
Vozzi D. , Licastro D. , Martelossi S. , Athanasakis E. , Gasparini P. , Fabretto A.
Mol. Syndromol.4:207-210(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALGS1 TRP-436

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